Ocean Drilling Project (ODP) Hole 625B from 890 m water on the West Florida carbonate ramp-slope provides a continuous 235 m long record of cyclic sedimentation responding to global climatic change and regional tectonics over the past 5.4 Ma. Relatively rapid sedimentation rates (> 5 cm/1000 yr) and a 30 cm sampling interval (6-10,000 yr) permit a high-resolution investigation of Milankovitch-influenced carbonate sedimentation on a continental margin. Total carbonate, percent coarse (> 63 mu m), and oxygen isotope data exhibit good correlation with established mid- and late-Pleistocene composite records, indicating that the climate signal recorded on the West Florida slope closely parallels the global climate signal obtained from deep-sea sediments.