The barrier-inlet system along the Gulf Coast of peninsular Florida has one of the most diverse morphologies of any barrier system in the world. The delicate balance between tidal- and wave-generated processes on this low-energy coast permits only slight changes in either of these processes to result in significant and rapidly developing morphologic responses. Some of these responses are the result of natural phenomena such as hurricanes opening tidal inlets, closure of inlets due to longshore transport of sediment, and changes in the availability of sediment. Tidal prism is the primary factor in controlling inlet morphology and is greatly influenced by anthropogenic activities in the backbarrier area. Human activity has also modified the coast in many ways over the past several decades, beginning with the construction of the first causeways in the 1920s. The various modifications by development have resulted in important morphodynamic changes in the barrier-inlet system. These include hardening the coast on the beach and at inlets, dredging and filling in backbarrier environments, and construction of fill-type causeways connecting the islands to the mainland. Construction of seawalls and jetties has inhibited normal coastal processes. Examples include the downdrift erosion at Blind Pass and Big Sarasota Pass. Construction of fill-type causeways between the barriers and the mainland has created artificial tidal divides that reduce the tidal prism at some inlets, thereby resulting in instability or closure such as Blind Pass and Dunedin Pass. This is further exacerbated by dredge and fill construction that reduces tidal prism by reducing the area of open water in the backbarrier. Dredging of the Intracoastal Waterway also results in a negative impact on selected inlets by channeling tidal flux away from some inlets. Impacts of these changes inhibit the barrier/inlet environments from responding to open coast processes.